Neko the Kitty
It's a cat comic! Neko lives with Alice the Human and Ellen the Other Human, and is a narcissistic nihilistic little jerkbag who's also a purry little sweetheart. There are more cats and people and it's been going since 2002 and the plot actually gets pretty involved, but at its heart it's a cat comic.
There was an ill-advised stint with a co-writer a while back which means the whole thing takes place in a world of magic and monsters now, but we killed off a main character and had a little mini-apocalypse so it's back under control now. Everyone loves Neko the Kitty check it out