Game Boyz is a comic about three gamers named Joe, Bob and Lorraine. Bob is your typical, trash-talking, hard-core gamer while Joe is a completely stupid one, Lorraine, on the other hand, is more of an average gamer, having a few hard-core gamer traits. Reggie Fils-Aime also makes frequent appearences in the comic. Bob and Joe live together as room-mates. The comics are generally centered around Joe being an idiot or Bob getting his ass kicked by Reggie.